MEET OUR INTERDISCIPLINARY TEAM

We welcome you to contact us regarding our research and involvement in collaborations.

Prof. Sonja Loges MD, PhD - Group leader Personalized Oncology Lab - Attending Physician Department of Oncology and Hematology with sections Bone Marrow Transplantation and Pneumology (II. Medical Clinic) & Institute of Tumor Biology

Sonja studied biochemistry and medicine at the University of Hamburg where she received her PhD and MD. She is a board-certified hematologist and oncologist and is currently leading the thoracic and molecular oncology programs of the II. Medical Clinic. She is also responsible for the „National Network Genomic Medicine“ (nNGM) center at the UKE. In these areas, she is conducting Phase 1-3 clinical trials and coordinating translational research programs with a focus on targeted therapies and liquid biopsies.

Sonja completed her Post-Doctoral training in the laboratory of Peter Carmeliet (Leuven) and is heading the Personalized Oncology Lab since 2010. She is holding a Heisenberg Professorship from the German Research Council (DFG) since 2016 and receives research funding from prestigious funding bodies including the European Research Council (ERC), the German Cancer Aid (Deutsche Krebshilfe), the Landesexzellenzstiftung Hamburg and the DFG. Sonja is participating in different collaborative research projects: the Schwerpunktprogramm (SPP ) µBone on malignant colonization of bone (DFG funded), the National Network Genomic Medicine  on molecular diagnostic and therapy in non-small cell lung cancer (DKH funded) and in a consortium on sex differences in infection, autoimmunity and cancer  (funded by Landesexzellenzstiftung Hamburg).

Sonja is supervising students from life sciences and medicine at different levels: bachelor thesis, master thesis, MD thesis, PhD thesis, clinician scientists and internships. She is a mentor in the mentorship program for excellent medical students, serves in the “Prüfungssausschuss” of the UKE and in the management board of the novel Mildred Scheel Nachwuchszentrum (MSZN ) funded by the DKH.

Dr. Isabel Ben Batalla PhD - Junior PI - Post-Doctoral Scientist

Isabel studied Molecular Biology at the University of Santiago de Compostela (Spain). She did her Ph.D. thesis at the School of Medicine in Santiago de Comspotela about the role of Prolactin and Pit-1 (a transcription factor) in promoting proliferation and metastasis in breast cancer, finishing in 2009. Afterwards, she moved to Hamburg for a postdoc and she has been working in the Loges lab since 2011. Isabel focuses on the role of the TAMR in hematological malignancies and the discovery of targeted therapies in solid tumors.

Starting in 2018 she is CoPI of the µBone project with the title ‚µBONE: Kolonisierung und Interaktionen von Tumorzellen innerhalb des Knochenmilieus‘.

Isabel is also involved in teaching medical students as well as supervising students working on their MD or PhD thesis in our lab. 

Victoria Gensch - Lab Manager

Victoria started studying Pharmacy in Hamburg but decided that full time lab work would be more her calling. After finishing her education as a biological lab technician at the School of Life Science in Hamburg she joined the Loges Lab in 2011, providing technical assistance and coordination to many different projects.

In 2017 she became Lab Manager and is now focusing on coordinating staff, studies and budgets and different managing tasks. Furthermore, she is still providing technical assistance as needed.

Dr. Corinna Albers-Leischner PhD - nNGM Project Coordinator- Post-Doctoral Scientist

Corinna studied biochemistry at the Leibniz University Hanover and Ludwig Maximilian University in Munich. Here, during her diploma thesis, she focused on asymmetric cell division in Drosophila melanogaster. She obtained her PhD followed by several years as a postdoc from the Technical University in Munich, where she established a new siRNA based retroviral vector system by which she could identify therapeutic targets in leukaemia models in vivo. After a second postdoc position at the Charité in Berlin working on an RNAi library screen she joined the Loges lab in summer 2018.

Here she is working as scientific coordinator for the national Network Genomic Medicine (nNGM) lung cancer for the location Hamburg.

Dr. Anne Marie Asemissen MD – Senior physician - Physician Scientist

Anne Marie studied Medicine in Greifswald, Berlin and Johannesburg (South Africa). She obtained her doctoral thesis in tumor immunology at the Free University, Berlin. She focuses on the immunemilieu in bone marrow, especially in malignant hematology. She has strong expertise in bone marrow morphology and is involved in clinical research in MDS, myeloma and myeloproliferative neoplasm. Her current project is about bone marrow mast cells in myeloid hematological malignancies and their association with disease progression. 

Dr. Antonia Beitzen-Heineke MD - Resident - Physician Scientist

Antonia studied medicine at the University of Würzburg as well as the University of Strasbourg. During her MD thesis, she focused on the role of iNKT cells in Aspergillus fumigatus infection. In 2015 she started her residency in the department of oncology and hematology at the University Hospital Hamburg Eppendorf. During her UCCH Research Fellowship starting in 2017 in the Loges lab, she focused on the role of TAM receptors in myeloproliferative neoplasms and continues to work on this topic.  

Nikolaus Berenbrok - MD thesis

Nikolaus studies medicine at the University of Hamburg. In his degree-related project (Studienarbeit), he focused on interactions between bone marrow stroma and dysplastic hematopoietic stem cells in Myelodysplastic Syndromes (MDS). Currently occupied with his M.D. thesis, he is working on the identification and targeting of mechanisms required for disease progression in MDS, especially focusing on the interplay in between bone marrow stroma and immune populations.

Lisa-Marie Böttcher - PhD student

Lisa-Marie studied Biology at the Georg-August-University of Göttingen as well as the University of Aarhus. In her Bachelor thesis, she was working on the influence of lysine glutarylation on the catalytic activity of the glutamate dehydrogenase. Afterwards, she undertook a M.Sc. in Biomedical Sciences at the Radboud University Nijmegen. She came to the Loges Lab in the beginning of 2018 for her Master thesis to work on the expression of biomarkers on circulating tumor cells of patients with non-small cell lung cancer (NSCLC). She continues on this topic in her PhD project while also focusing on innovative liquid biopsy approaches.

Janik Engelmann - MD thesis

Janik is a medical student at the University Hospital Hamburg-Eppendorf and member of the Loges lab since 2015. He is working on his MD thesis and studies the role of TAM receptor tyrosine kinases Tyro3, Axl, and Mer together with their cognate agonists Gas6 and Pros1 in physiological setting and disease including cancer progression, cell differentiation and maintenance of homeostasis in organ systems.

Lena Hoffmann - biological technician (BTA)

Lena studied at the School of Life Science in Hamburg and graduated as a biology laboratory technician (BTA) in 2018 after which she joined the Loges lab. She works on Next Generation Sequencing and supports her colleagues with animal work. Lena is responsible for sample processing, documentation and storage for the biobank. Furthermore she takes care of the organisation of the nitrogen tanks.

Dr. Melanie Janning MD - Resident - Physician Scientist

Melanie studied Medicine at the Philipps University in Marburg, Germany. During that time she did clinical internships in Switzerland (Zug) and the UK (Hereford, Birmingham University). For her MD at the Philips University, she worked on mRNA export proteins. Melanie also obtained a Diploma (equivalent to a M.Sc. degree) in Human Biology at the Philipps University. During her diploma thesis at the Oxford University in the UK, she investigated the heterogeneity of Head and Neck Cancer by performing kinase-centered proteomics.  Afterwards she worked on protein-protein interactions of SH2- and SH3-containing proteins at the Oxford University.

Since 2010, Melanie has a resident position in clinical hematology and oncology at the University Medical Center Eppendorf in Hamburg and her clinical focus is on acute leukemias and thoracic cancers.  She joined the Loges lab in 2012. Her work here focuses on mechanisms of resistance towards anti-angiogenic cancer drugs. Another important project is the use of liquid biopsies (i.e. circulating tumor cell or cell free tumor DNA) in order to better understand resistance to immune checkpoint inhibitors and identify biomarker allowing a more personalized treatment of cancer patients.

Melanie is also involved in teaching medical students as well as supervising students working on their MD or PhD thesis in our lab. 

Franca Kobus - MD thesis

Franca is a medical student at the University of Hamburg. She is currently working on her M.D. thesis in the Personalized Oncology Lab which she started 2017. Her thesis is about circulating tumor cells of lung cancer patients with a focus on the expression of PD-L1.

Renke Tim Lucas - biological technician (BTA)

Renke studied at the School of Life Science in Hamburg and graduated as a biology laboratory technician (BTA) in 2019, after which he joined the Loges Lab. He works in the µBone focussing on the role of TAM receptor tyrosine kinases Tyro3, Axl, and Mer together with their cognate agonists Gas6 and Pros1 in cell differentiation and maintenance. He is also supporting his colleagues in animal work, as well as organising the liquid nitrogen tank. Furthermore he helps unravel the biological effects of an antibody-drug conjugate targeting human AXL and its therapeutic potential in Axl+ hematologic malignancies.

Lara Meier - PhD student

Lara studied Biology at the University of Hamburg. During her Bachelor Thesis she focused on the establishment of T7 RNA polymerase in vitro transcription system as a tool to synthetize different RNAs. Afterwards, she studied Humanbiologie/Biomedical Science at the Philipps-University in Marburg and obtained her M.Sc. degree working on her thesis project “ADAM8 dependence of miRNAs in Glioblastoma multiforme”. After a five-months internship at the Biomedical Research Centre (UBC, Vancouver) Lara started her PhD in the Loges lab. Her project is about developing novel strategies to eradicate malignant cells in the blood and bone marrow.

Sarina Päsler - biological technician (BTA)

Sarina graduated as a biological technician in 2016. She studied at the School of Life Science in Hamburg.

 

She works on the Next Generation Sequencing and supports her colleagues with animal work. Futhermore she takes care of all mouse strains. Her own project is about Circulating Tumor Cells in Lung Cancer and the identification of new immuncheckpoints

Dr. Jochim Reinert MD – Resident - Physician Scientist

Jochim studied medicine at the Ruhr-Universität Bochum and Georg-August-Universtität Göttingen. During his studies at the Universität Göttingen he completed the Jacob-Henle scholarship program for experimental medicine. He obtained his doctoral degree (Dr. med.) after doing research on Amyloid-Plaque composition in sporadic and familial Alzheimer’s disease. After his studies he started working at the II. Medical Department at UKE. With his current research project on the bone marrow microenvironment, Jochim aims to identify mechanisms of chemoresistance and immune escape in acute myeloid leukemia.

Andia-Louisa Therany - MD thesis

Andia-Louisa is a medical student at the University of Hamburg and is currently working on her M.D. thesis which she started in 2018. The project is about circulating tumor cells/liquid biopsy, with a focus on lung cancer patients undergoing immune checkpoint therapy. 

Florian Udonta MD - Physician Scientist

Florian studied biochemistry/molecular biology and medicine at the University of Hamburg. He obtained his degree (diploma) in biochemistry and molecular biology at the University of Hamburg by characterizing myeloid-derived suppressor cells (MDSC) in colorectal- and pancreatic cancer patients. In his M.D. project, he is focusing his research on a novel strategy to improve the efficacy of anti-angiogenic therapy by reducing tumor-infiltrating MDSC with all-trans retinoic.

Maria Elena Vargas Delgado - PhD student

Maria-Elena studied Biotechnology at the ‘Universidad Politecnica de Valencia’ (Spain). During her Bachelor thesis, she focused on studying the effect of ANKK1 overexpression in neuroblastoma cell lines at the Principe Felipe Research Centre. She obtained her M.Sc. Degree in Biotherapies and Immunology at the ‘Université Pierre et Marie Curie’ (France). During her Master thesis, she participated in an exchange program at the University Medical Centre Hamburg Eppendorf (UKE), were she focused on investigating the role of Tyro3 in Acute Myeloid Leukemia (AML) in the Loges lab. Maria-Elena´s PhD project that started in 2017 is about the influence of sex differences on the immune response in AML. 

Dr. Janna-Lisa Velthaus MD – Resident - Physician Scientist

Janna-Lisa studied medicine at the Heinrich-Heine University Düsseldorf as well as the University Clinic Hamburg-Eppendorf. During her medical thesis, she focused on the angiogenesis of malignant peripheral nerve sheath tumors. From 2013-2014 she worked as a resident at the department of cardiology at Segeberger Kliniken. In July 2014 she started her residency at the department of Hemtalogy and Oncology at the University Clinic Hamburg-Eppendorf. Among others, her project sponsored by an UCCH Research Fellowship in the Loges lab is about clinical translation of potential biomarkers for the efficacy of antiangiogenic therapies. Her clinical tasks focus on thoracic oncology and precision oncology.

Jonas Waizenegger MD – Resident - Physician Scientist

Jonas studied Medicine at the University of Hamburg. His connection to scientific work was made possible by the mentoring program for excellent students where he became a mentee of Sonja Loges and started to work on his medical thesis in 2013. His work is focused on the role of TAM Receptors and their function in cancer with a focus the role they play in multiple myeloma. Since his MD degree he is working as a physician in the department of hematology and oncology of the University hospital Hamburg-Eppendorf.

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​​Universitätsklinikum Hamburg-Eppendorf

Campus Forschung (N27)

Personalized Oncology Lab

Prof. Dr. Dr. Sonja Loges

Martinistr. 52
20246 Hamburg

CONTACT

Victoria Gensch
Phone (Lab): +49 (0)40 7410 51992

Phone (Office): +49 (0)40 7410 57420
Fax: +49 (0)40 7410 55896

E-Mail: v.gensch@uke.de

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